Table 2.
Univariable and multivariable regression of preselected factors on recurrence-free survival
| Variable | Category | Univariable regression | Multivariable regression | |||||
|---|---|---|---|---|---|---|---|---|
| HR1 | 95% CI1 | p-value | HR1 | 95% CI1 | p-value | |||
| Age | – | – | 1.00 | 0.99, 1.00 | 0.4 | 1.00 | 0.99, 1.00 | 0.3 |
| Sex | Female | (vs. male) | 0.91 | 0.78, 1.06 | 0.2 | 0.88 | 0.75, 1.03 | 0.1 |
| Sidedness | Right-sided | (vs. left-sided) | 0.95 | 0.79, 1.14 | 0.6 | 0.98 | 0.80, 1.19 | 0.8 |
| Rectosigmoid | (vs. left-sided) | 1.18 | 0.99, 1.40 | 0.1 | 1.18 | 0.98, 1.41 | 0.1 | |
| Differentiation grade | Poor | (vs. moderate/well) | 1.16 | 0.90, 1.49 | 0.2 | 1.38 | 1.03, 1.84 | 0.030 |
| Stage | Stage IV | (vs. stage I–III) | 1.22 | 1.04, 1.43 | 0.017 | 1.24 | 1.03, 1.49 | 0.024 |
| BRAFV600E mutation status | Mutation | (vs. wildtype) | 0.96 | 0.65, 1.43 | 0.9 | 1.41 | 0.82, 2.42 | 0.2 |
| RAS mutation status | Mutation | (vs. wildtype) | 1.11 | 0.93, 1.33 | 0.2 | 1.15 | 0.92, 1.42 | 0.2 |
| Mismatch repair status | dMMR | (vs. pMMR) | 0.62 | 0.44, 0.88 | 0.007 | 0.57 | 0.38, 0.87 | 0.009 |
| Type of local treatment | CRS/HIPEC only | (vs. CRLM only) | 0.84 | 0.69, 1.02 | 0.1 | 0.90 | 0.72, 1.12 | 0.3 |
| Perioperative chemotherapy | Received | (vs. not received) | 1.07 | 0.93, 1.24 | 0.3 | 0.91 | 0.77, 1.08 | 0.3 |
Bold-values are considered significant (p-value < 0.05)
CI confidence interval, CRLM colorectal liver metastasectomy, CRS/HIPEC cytoreductive surgery/hyperthermic intraperitoneal chemoperfusion, dMMR deficient mismatch repair, HR hazard ratio for RFS, mCRC metastatic colorectal cancer