TABLE 1.
Susceptibility in RPMI 1640 brotha
| Isolate | N | Putative statusb | MIC (μg/ml)c
|
|||||
|---|---|---|---|---|---|---|---|---|
| 48 h
|
72 h
|
|||||||
| Range | Geo M | Mode | Range | Geo M | Mode | |||
| CN 1 | 31 | S | 0.0625–0.5 | 0.26 | 0.25 | 0.25–1 | 0.47 | 0.5 |
| CN 2 | 32 | S | 0.0625–0.5 | 0.24 | 0.25 | 0.125–2 | 0.41 | 0.25 |
| CN 3 | 29 | S | 0.0625–0.5 | 0.27 | 0.25 | 0.125–1 | 0.36 | 0.5 |
| CN 4 | 30 | S | 0.125–0.25 | 0.18 | 0.25 | 0.125–2 | 0.4 | 0.25 |
| CN 5 | 30 | S | 0.125–0.5 | 0.22 | 0.25 | 0.125–1 | 0.37 | 0.5 |
| CN 6 | 34 | S | 0.125–1 | 0.24 | 0.25 | 0.125–8 | 0.45 | 0.5 |
| CN 7 | 31 | S | 0.125–0.5 | 0.29 | 0.25 | 0.125–8 | 0.54 | 0.5 |
| CN 9 | 37 | S | 0.0625–0.5 | 0.15 | 0.125 | 0.125–2 | 0.52 | 0.5 |
| CN 12 | 20 | S | 0.125–0.25 | 0.24 | 0.25 | 0.25–0.5 | 0.31 | 0.25 |
| CN 8 | 44 | R | 0.5–2 | 0.9 | 1 | 0.5–4 | 1.31 | 1 |
| CN 10 | 20 | R | 1.0–2.0 | 1.27 | 1 | 2.0–4.0 | 2.07 | 2 |
| CN 11 | 20 | R | 0.5–2 | 1.1 | 1 | 2 | 2 | 2 |
| Clinical | 72 | S | 0.125–0.5 | 0.36 | 0.5 | 0.125–1 | 0.46 | 0.5 |
a
Eighty-four C. neoformans isolates were tested by the M27-A broth microdilution methodology in RPMI 1640 medium. Isolates CN 1 to CN 12 were tested the indicated number of times (N), while the 72 clinical isolates were tested once each. MICs were determined after 48 and 72 h of incubation.
b
S, susceptible; R, resistant.
c
Range, range of MICs; Geo M, geometric mean MIC; Mode, modal MIC.