TABLE 2.
Susceptibility in antibiotic medium 3 brotha
| Isolate | N | Putative statusb | MIC (μg/ml)c
|
|||||
|---|---|---|---|---|---|---|---|---|
| 48 h
|
72 h
|
|||||||
| Range | Geo M | Mode | Range | Geo M | Mode | |||
| CN 1 | 29 | S | 0.125–0.25 | 0.19 | 0.25 | 0.125–0.5 | 0.33 | 0.5 |
| CN 2 | 27 | S | 0.0625–0.25 | 0.19 | 0.25 | 0.125–1 | 0.35 | 0.25 |
| CN 3 | 27 | S | 0.125–0.5 | 0.26 | 0.25 | 0.125–2 | 0.42 | 0.5 |
| CN 4 | 28 | S | 0.125–0.25 | 0.19 | 0.25 | 0.25–0.5 | 0.35 | 0.25 |
| CN 5 | 29 | S | 0.0625–0.25 | 0.1 | 0.0625 | 0.0625–0.5 | 0.25 | 0.25 |
| CN 6 | 28 | S | 0.0625–0.25 | 0.2 | 0.25 | 0.25–1 | 0.34 | 0.25 |
| CN 7 | 29 | S | 0.0625–0.25 | 0.18 | 0.25 | 0.125–1 | 0.36 | 0.5 |
| CN 9 | 38 | S | 0.0625–0.25 | 0.18 | 0.25 | 0.25–1 | 0.38 | 0.5 |
| CN 12 | 20 | S | 0.125–0.25 | 0.14 | 0.125 | 0.125–0.25 | 0.18 | 0.25 |
| CN 8 | 44 | R | 0.5–2 | 0.9 | 1 | 1.0–8.0 | 1.6 | 2 |
| CN 10 | 20 | R | 1.0–2.0 | 1.1 | 1 | 1.0–2.0 | 1.18 | 1 |
| CN 11 | 20 | R | 1.0–2.0 | 1 | 1 | 1.0–2.0 | 1.03 | 1 |
| Clinical | 72 | S | 0.0625–0.25 | 0.17 | 0.25 | 0.125–0.5 | 0.25 | 0.25 |
a
Eighty-four C. neoformans isolates were tested by the microdilution methodology in broth in antibiotic medium 3. Isolates CN 1 to CN 12 were tested the indicated number of times (N), while the 72 clinical isolates were tested once each. MICs were determined after 48 and 72 h of incubation.
b
S, susceptible; R, resistant.
c
Range, range of MICs; Geo M, geometric mean MIC; Mode, modal MIC.