TABLE 4.
Susceptibility on RPMI 1640 agara
| Isolate | N | Putative statusb | MIC (μg/ml)c
|
|||||
|---|---|---|---|---|---|---|---|---|
| 48 h
|
72 h
|
|||||||
| Range | Geo M | Mode | Range | Geo M | Mode | |||
| CN 1 | 3 | S | 0.19–0.25 | 0.23 | 0.25 | 0.38 | 0.38 | 0.38 |
| CN 2 | 3 | S | 0.125 | 0.125 | 0.125 | 0.25 | 0.25 | 0.25 |
| CN 3 | 3 | S | 0.19–0.125 | 0.14 | 0.125 | 0.19–0.38 | 0.26 | 0.19 |
| CN 4 | 3 | S | 0.094–0.25 | 0.14 | 0.094 | 0.25 | 0.25 | 0.25 |
| CN 5 | 3 | S | 0.064–0.094 | 0.07 | 0.064 | 0.19 | 0.19 | 0.19 |
| CN 6 | 3 | S | 0.125–0.19 | 0.16 | 0.19 | 0.19–0.25 | 0.23 | 0.25 |
| CN 7 | 3 | S | 0.094–0.125 | 0.11 | 0.125 | 0.19 | 0.19 | 0.19 |
| CN 9 | 3 | S | 0.125 | 0.125 | 0.125 | 0.25 | 0.25 | 0.25 |
| CN 12 | 3 | S | 0.125 | 0.125 | 0.125 | 0.19 | 0.19 | 0.19 |
| CN 8 | 3 | R | 2.0–4.0 | 2.8 | 2 | 4.0–6.0 | 5.2 | 6 |
| CN 10 | 3 | R | 1.5–2 | 1.65 | 1.5 | 2.0–4.0 | 2.5 | 2 |
| CN 11 | 3 | R | 2 | 2 | 2 | 2 | 2 | 2 |
| Clinical | 72 | S | 0.006–0.38 | 0.086 | 0.094 | 0.064–0.5 | 0.162 | 0.19 |
a
Each named Cryptococcus isolate was tested the indicated number of times by the E-test methodology in 2% glucose-supplemented RPMI 1640 agar. Isolates CN 1 to CN 12 were tested the indicated number of times (N), while the 72 clinical isolates were tested once each. MICs were determined after 48 and 72 h of incubation.
b
S, susceptible; R, resistant.
c
MIC range, range of MICs; Geo M, geometric mean MIC; Mode, modal MIC.