Table 3.
cytoBand | Gene | Function | ORIGIN analysis | ORIGIN OR | ORIGIN p value | ORIGIN AF case | ORIGIN AF ctrl | N p < 1e-5 | Clumped |
---|---|---|---|---|---|---|---|---|---|
1q23.3 | NOS1AP | intronic | Severity | 1.734 | 3.49E-06 | 0.220 | 0.143 | 3 | 11 |
2q14.3 | LINC01826; LOC107985820 | intergenic | Severity | 12.768 | 7.79E-07 | 0.024 | 0.003 | 7 | 7 |
2q24.1 | KCNJ3 | intronic | Susceptibility | 0.671 | 3.38E-06 | 0.486 | 0.586 | 2 | 27 |
4q28.3 | LINC02479; SNHG27 | intergenic | Severity | 0.555 | 5.44E-07 | 0.766 | 0.841 | 14 | 126 |
6q13 | LOC101928516; COL12A1 | intergenic | Severity | 11.305 | 1.75E-06 | 0.020 | 0.003 | 4 | 5 |
6q16.3 | GRIK2; NONE | intergenic | Severity | 6.276 | 6.74E-06 | 0.026 | 0.006 | 4 | 39 |
6q24.2 | UTRN | intronic | Severity | 2.643 | 2.41E-06 | 0.079 | 0.034 | 2 | 6 |
7p15.3 | DNAH11 | intronic | Severity | 2.781 | 5.90E-07 | 0.088 | 0.038 | 2 | 20 |
10p12.2 | MSRB2; PTF1A | intergenic | Severity | 0.462 | 8.48E-06 | 0.042 | 0.091 | 3 | 66 |
12p13.31 | PEX5; ACSM4 | intergenic | Susceptibility | 0.500 | 1.50E-06 | 0.074 | 0.138 | 3 | 37 |
12q13.2 | MUCL1; TESPA1 | intergenic | Susceptibility | 0.268 | 6.42E-06 | 0.014 | 0.043 | 2 | 4 |
13q14.11 | LINC00548; LINC00598 | intergenic | Susceptibility | 1.558 | 3.40E-06 | 0.356 | 0.263 | 2 | 8 |
14q12 | STXBP6; NOVA1 | intergenic | Severity | 7.363 | 5.97E-07 | 0.029 | 0.005 | 2 | 1 |
14q32.12 | RIN3 | intronic | Susceptibility | 0.331 | 1.81E-06 | 0.024 | 0.064 | 2 | 1 |
16q22.1 | TERF2; CYB5B | intergenic | Susceptibility | 0.256 | 2.14E-06 | 0.011 | 0.044 | 2 | 2 |
18q22.2 | RTTN; SOCS6 | intergenic | Severity | 2.779 | 5.13E-06 | 0.068 | 0.031 | 3 | 10 |
21q21.3 | APP; CYYR1-AS1 | intergenic | Susceptibility | 0.621 | 3.67E-06 | 0.204 | 0.288 | 6 | 78 |
Loci for which at least two markers reached a p value<1x10−5.