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. 2023 Aug 28;30:286–300. doi: 10.1016/j.omto.2023.08.012

Figure 6.

Figure 6

Combining MK-1775 and docetaxel improves EAC patient-derived xenograft mouse model survival with smoking in vivo

(A) Graphic summary of the EAC patient-derived xenograft experimental design. (B) Tumor growth curves in eight experimental groups with or without smoking. (C) Tumor size in eight experimental groups with or without smoking at the end of the experiment. (D and E) Probability of survival in non-smoking and smoking groups with single or combined drug treatment. (F) Western blot analysis of WEE1, BCL-2, PARP, cleaved PARP (Cl-PARP), and β-actin in mouse xenografts. (G) qRT-PCR analysis of miR-195-5p expression in mouse xenografts. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001.