WEE1 inhibition induces apoptosis, and docetaxel promotes tubulin destabilization in EAC PDXs
(A) Immunofluorescence staining of cleaved caspase-3 (red), DAPI (blue) in EAC PDXs described in Figure 6. Scale bar, 50 μm. (B) Quantification data of (A). (C) Immunofluorescence staining of detyrosinated tubulin (green, stable tubulin) and DAPI (blue) in EAC PDXs described in Figure 6. Scale bar, 50 μm. (D) Quantification of (C) ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.