TABLE 1.

MR estimates for the association between gut microbiota and acne.

Bacterial taxa (exposure)	nSNPs	Method	OR (95% CI)	p‐value	q‐value	Heterogeneity test Method	Q	p	Pleiotropy test P intercept	F
Allisonella	8	IVW	1.42(1.18‐1.70)	0.0002	0.0095	MR Egger	7.5303	0.2746	0.5220	141.7226
		MR Egger	2.21(0.60‐8.12)	0.2767	0.9962	IVW	8.1101	0.3230
		Weighted median	1.36(1.06‐1.74)	0.0140	0.8358
		Weighted mode	1.41(1.01‐1.95)	0.0814	0.9927
Bacteroides	8	IVW	2.25(1.48‐3.42)	0.0001	0.0095	MR Egger	7.8403	0.2500	0.8000	25.6915
		MR Egger	1.64(0.15‐17.71)	0.6964	0.9962	IVW	7.9319	0.3386
		Weighted median	1.77(1.02‐3.07)	0.0408	0.9660
		Weighted mode	1.53(0.76‐3.12)	0.2720	0.9927
Candidatus_Soleaferrea	9	IVW	0.75 (0.60‐0.95)	0.0149	0.3896	MR Egger	2.5464	0.9236	0.7951	69.0352
		MR Egger	1.04(0.97‐11.19)	0.9740	0.9962	IVW	2.6191	0.9560
		Weighted median	0.81(0.60‐1.09)	0.1582	0.9660
		Weighted mode	0.84(0.54‐1.31)	0.4644	0.9927
Eubacterium_coprostanoligenes_group	13	IVW	0.67(0.47‐0.95)	0.0230	0.5013	MR Egger	13.9713	0.2346	0.7524	23.3107
		MR Egger	0.83(0.20‐3.40)	0.8028	0.9962	IVW	14.1042	0.2941
		Weighted median	0.71(0.45‐1.12)	0.1375	0.9660
		Weighted mode	0.69(0.34‐1.41)	0.3278	0.9927
Fusicatenibacter	18	IVW	0.71(0.52‐0.97)	0.02897	0.5422	MR Egger	20.5265	0.1974	0.6537	23.4805
		MR Egger	0.55(0.17‐1.76)	0.3275	0.9962	IVW	20.7946	0.2356
		Weighted median	0.63(0.43‐0.93)	0.0191	0.8358
		Weighted mode	0.56(0.31‐1.03)	0.0810	0.9927
Lactobacillus	8	IVW	0.72 (0.58‐0.90)	0.0046	0.1491	MR Egger	2.4210	0.8772	0.2740	81.2322
		MR Egger	1.00(0.56‐1.78)	0.9962	0.9962	IVW	3.8703	0.7946
		Weighted median	0.78(0.58‐1.05)	0.1001	0.9660
		Weighted mode	0.81(0.56‐1.17)	0.2950	0.9927
Ruminococcus_torques_group	7	IVW	0.41 (0.25‐0.65)	0.0002	0.0095	MR Egger	3.1094	0.6831	0.2465	20.7688
		MR Egger	1.57(0.20‐12.45)	0.6886	0.9962	IVW	4.8313	0.5656
		Weighted median	0.40(0.21‐0.76)	0.0050	0.6511
		Weighted mode	0.39(0.16‐0.91)	0.0728	0.9927