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. 2023 Sep 4;14:1215065. doi: 10.3389/fphar.2023.1215065

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Copyright © 2023 Li, Mak, Ruan, Dong, Zheng, Gu, Guo, Zhang, Cheng, Ruan, Shi, Zang, Zhu, He, Xiang, Wang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plot of the covariate impact on the steady state area under the curve (AUCss), peak concentration (Cmax,ss) and trough concentration (Cmin,ss). Simulations based on the uncertainty of fixed-effect parameters only.