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. 2023 Sep 4;14:1237796. doi: 10.3389/fendo.2023.1237796

Figure 1.

Figure 1

Glucose uptake is induced by ApN. (A) Schematic of experimental design. 4 months-old wild-type or APP/PSN1 mice were fed with either a control diet or high-fat diet (HFD), and received intraperitoneal injections of adiponectin (ApN), or resistin 3 times per week for 4 months. (B, C) Radioactive glucose was tail‐vein injected and 15 min later glucose uptake was measured in the cortex or hippocampus. (D-F) The effects of the HFD and adipokines treatments on the mRNA levels of the glucose transporters Glut1, Glut3, and Glut4 were measured in the cortex and hippocampus using qRT–PCR. Means ± SEM are shown (n = 5 mice per condition in 3 technical replicates). Statistical significance was determined by one-way ANOVA followed by Bonferroni’s multiple comparison posthoc test. *p < 0.05 and **p < 0.01, compared with control group; &p < 0.05, compared with specified group.