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. 2023 Sep 4;14:1237796. doi: 10.3389/fendo.2023.1237796

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Copyright © 2023 Cisternas, Gherardelli, Gutierrez, Salazar, Mendez-Orellana, Wong and Inestrosa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucose metabolism is restored after ApN treatment in hippocampal slices Hippocampal slices were obtained from WT or APP/PSN1 mice treated with either ApN or resistin and the (A, B) uptake of glucose, (C, D) glycolytic flux, (E, F) ATP/ADP ratio and (G, H) pentose phosphate flux (PPP) were measured. Means ± SEM are shown (n = 4-5 mice per condition in 3 technical replicates). Statistical significance was determined by either one-way ANOVA (C-H) or two-way ANOVA (A), followed by Bonferroni’s multiple comparison posthoc test. *p < 0.05, **p < 0.01 and ***p < 0.001, compared with control group; ^&p < 0.05 and ^&&p < 0.01, ^&&&p < 0.001 compared with specified group.