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. 2023 Sep 4;14:1237796. doi: 10.3389/fendo.2023.1237796

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Copyright © 2023 Cisternas, Gherardelli, Gutierrez, Salazar, Mendez-Orellana, Wong and Inestrosa

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ApN recovered and resistin further deteriorated cognitive failure induced by MetS. WT and APP/PSN1 mice fed with control or HFD in the presence of either ApN or resistin were subjected to cognitive tests, including open field (A) percentage of time moving and (B) the number of crossing lines, (C) novel object localization (NOL) and (D) novel object recognition (NOR). Means ± SEM are shown (n = 6-7 mice per condition in 3 technical replicates). Statistical significance was determined by one-way ANOVA, followed by Bonferroni’s multiple comparison posthoc test. *p < 0.05 and **p < 0.01, compared with control group; ^&p < 0.05 and ^&&p < 0.01, compared with specified group.