Figure 4.

ApN restores Aβ₄₂/Aβ₄₀ ratio in the hippocampus of MetS-induced APP/PSN1 mice. (A, B) the levels of Aβ₄₀ and Aβ₄₂ were measured in the hippocampus of APP/PSN1 mice fed with control or HFD in the presence of either ApN or resistin and (C) the Aβ₄₂/Aβ₄₀ ratio was calculated accordingly. (D, E) the levels of Aβ₄₀ and Aβ₄₂ were measured in the hippocampus of APP/PSN1 mice fed with control or HFD in the presence of either ApN or resistin and (F) the Aβ₄₂/Aβ₄₀ ratio was calculated accordingly. Means ± SEM are shown (n = 5 mice per condition in 3 technical replicates). Statistical significance was determined by one-way ANOVA, followed by Bonferroni’s multiple comparison posthoc test. *p < 0.05 and **p < 0.01, compared with control group; ^&p < 0.05 and ^&&p < 0.01, compared with specified group.