Figure 3. Associations Between Neighborhood Disadvantage, Microstructure, Threat Reactivity, and Posttraumatic Stress Disorder (PTSD) Symptoms.

A, Neighborhood disadvantage was associated with anterior cingulate cortex (ACC) threat reactivity via cingulum-cingulate gyrus (CGC) fractional anisotropy (FA) values (path a), and PTSD symptoms moderated the association between microstructure and reactivity (path b), even after adjusting for income, lifetime trauma, sex, and age. B, There were conditional indirect effects of Area Deprivation Index (ADI) and ACC reactivity via CGC FA at higher but not lower PTSD symptoms. Coefficients are standardized.