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. 2023 Sep 18;6(9):e2334483. doi: 10.1001/jamanetworkopen.2023.34483

Table 2. General Linear Models for Task Reactivity.

ROI Variablea Standardized coefficient, β t Statistic Uncorrected P value
Threat task (n = 280)
Hippocampus Intercept NA −1.86 .06
ADI 0.15 2.30 .02
Age 0.05 0.87 .39
Sex 0.01 0.09 .93
Income −0.03 −0.49 .63
LEC-5 0.04 0.61 .54
Amygdala Intercept NA −1.57 .12
ADI 0.09 1.50 .14
Age 0.09 1.38 .17
Sex 0.07 1.22 .23
Income <−0.01 −0.04 .97
LEC-5 0.11 1.87 .06
ACC Intercept NA −1.59 .11
ADI 0.16 2.56 .01
Age <−0.01 −0.05 .96
Sex −0.01 −0.24 .81
Income <0.01 <.01 >.99
LEC-5 −0.02 −0.35 .73
Subgenual ACC Intercept NA −0.77 .44
ADI 0.02 0.26 .80
Age 0.04 0.67 .50
Sex −0.03 −0.49 .63
Income 0.05 0.73 .47
LEC-5 −0.06 −0.91 .37
Insula Intercept NA −1.16 .25
ADI 0.20 3.20 .001
Age −0.02 −0.38 .70
Sex −0.04 −0.73 .47
Income 0.01 0.17 .87
LEC-5 <0.01 0.05 .96
Reward task (n = 244)
Amygdala Intercept NA 2.76 .006
ADI −0.07 −0.91 .37
Age −0.10 −1.34 .18
Sex <0.01 0.07 .94
Income 0.07 0.97 .33
LEC-5 −0.13 −2.04 .04
Nucleus accumbens Intercept NA 2.53 .012
ADI 0.10 1.41 .16
Age −0.04 −0.66 .51
Sex −0.04 −0.62 .54
Income 0.08 1.17 .24
LEC-5 0.03 0.53 .60
OFC Intercept NA −0.80 .43
ADI <0.01 0.15 .89
Age 0.07 1.06 .29
Sex −0.02 −0.33 .74
Income 0.07 1.03 .31
LEC-5 −0.05 −0.75 .46
ACC Intercept NA −2.32 .02
ADI 0.05 0.80 .42
Age 0.05 0.79 .43
Sex −0.10 −1.52 .13
Income 0.20 3.05 .002
LEC-5 −0.05 −0.76 .45
Insula Intercept NA −1.33 .18
ADI 0.01 0.12 .91
Age <−0.01 −0.02 .99
Sex −0.03 −0.43 .67
Income 0.13 1.88 .06
LEC-5 −0.06 −0.85 .40

Abbreviations: ACC, anterior cingulate cortex; ADI, Area Deprivation Index; OFC, orbitofrontal cortex; LEC-5, Life Events Checklist for the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) (DSM-5); NA, not applicable; ROI, region of interest.

a

All variables except sex were continuous and defined as per-unit increases.