Table 1.
Selected characteristics of the included studies.
| Study, country | Total | Men/Women | Drug | N | Age | Duration | Dose | Out/Inpatient | Duration of illness | Symptom severity | Concomitant txt | Neurocognitive outcomes | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n) | (%) | (mean ± SD. year) | (week) | (mg/day) | (year) | (BPRS or PANSS) | |||||||
| 1 | Sumiyoshi et al. | 26 | 57.7/42.3 | 6 | 30 (fixed) | Outpatient | BPRS | Typical antipsychotic | WMS-R(Revised verbal memory composite) Wisconsin Card Sorting Test |
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| (2001) Japan | Tan | 15 | Tan: 27.8 ± 6.30, | Tan: 6.3 ± 4.30, | Tan: 16.8 ± 9.00 | ||||||||
| Pbo | 11 | Pbo: 31.8 ± 9.40 | Pbo: 7.5 ± 5.40 | Pbo: 18.9 ± 8.70 | |||||||||
| 2 | Sumiyoshi et al. | 73 | 56.2/43.8 | 24 | 30 (fixed) | Outpatient | BPRS | Atypical antipsychotic | Auditory Consonants Trigram California Verbal Learning Test Wisconsin Card Sorting Test |
||||
| (2007) USA | Bus | 36 | Bus: 40.5 ± 11.80, | Bus: 19.0 ± 11.20 | Bus: 20.6 ± 8.00 | ||||||||
| Pbo | 37 | Pbo: 39.7 ± 12.50 | Pbo: 19.0 ± 13.50 | Pbo: 20.0 ± 8.60 | |||||||||
| 3 | PišKulić et al. | 18 | 77.8/22.2 | 6 | 21.6 ± 3.75 | Outpatient | PANSS | Atypical antipsychotic | Hopkins verbal learning test The n-back component of the task |
||||
| (2009) Australia | Bus | 9 | Bus: 43.4 ± 10.30 | Bus: 15.2 ± 10.20 | Bus:52.8 ± 9.30 | ||||||||
| Pbo | 9 | Pbo: 37.2 ± 13.70 | Pbo: 11.7 ± 9.40 | Pbo:55.4 ± 14.90 | |||||||||
| 4 | Wang et al. | 196 | 70.9/29.1 | 24 | 30 (fixed) | PANSS | Atypical antipsychotic | WAIS-RC (digital span test, digital symbols) | |||||
| (2019) China | Bus | 99 | Bus: 39.81 ± 10.11 | – | Bus: 12.01 ± 8.87 | Bus: 48.03 ± 12.95 | |||||||
| Con | 97 | Con: 39.02 + 9.56 | Con: 11.24 + 8.28 | Con: 47.49 + 12.32 |
BPRS, Brief Psychiatric Rating Scale; PANSS, Positive and Negative Syndrome Scale; Bus, buspirone; Pbo, placebo; Tan, tandospirone; Con, Control; txt, treatment.