Table 5.
Association between Three Protein Dietary Indices (DPS, APS, and PPS) with IE, Allergic Sensitization, and AD Presentation among 11,494 Young Chinese adults from SMCGES Population
| Dietary Scores | IE Presentation1 |
Allergic Sensitization to HDMs2 |
AD Presentation3 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-Value4 | OR | 95% CI | P-Value4 | OR | 95% CI | P-Value4 | |
| DPS, unadjusted | |||||||||
| Low total protein score | 1.000 | REF | — | 1.000 | REF | — | 1.000 | REF | — |
| Moderate total protein score | 0.895 | 0.707–1.133 | 0.354 | 1.255 | 1.134–1.390 | 1.210×10−5 | 1.130 | 0.962–1.328 | 0.137 |
| High total protein score | 1.003 | 0.794–1.268 | 0.979 | 1.501 | 1.355–1.661 | 5.510×10−15 | 1.493 | 1.276–1.749 | 6.130×10−7 |
| DPS, adjusted | |||||||||
| Low total protein score | 1.000 | REF | — | 1.000 | REF | — | 1.000 | REF | — |
| Moderate total protein score | 0.940 | 0.692–1.277 | 0.689 | 1.205 | 1.058–1.373 | 0.005 | 1.136 | 0.918–1.406 | 0.242 |
| High total protein score | 1.036 | 0.771–1.421 | 0.775 | 1.409 | 1.236–1.606 | 5.060×10−3 | 1.397 | 1.133–1.724 | 0.002 |
| APS, unadjusted | |||||||||
| Low animal protein score | 1.000 | REF | — | 1.000 | REF | — | 1.000 | REF | — |
| Moderate animal protein score | 0.949 | 0.757–1.189 | 0.649 | 1.152 | 1.046–1.270 | 0.004 | 1.070 | 0.918–1.247 | 0.384 |
| High animal protein score | 0.997 | 0.791–1.256 | 0.983 | 1.446 | 1.310–1.595 | 2.240×10−13 | 1.447 | 1.245–1.682 | 1.550×10−6 |
| APS, adjusted | |||||||||
| Low animal protein score | 1.000 | REF | — | 1.000 | REF | — | 1.000 | REF | — |
| Moderate animal protein score | 1.000 | 0.743–1.346 | 0.998 | 1.116 | 0.984–1.266 | 0.088 | 1.010 | 0.821–1.242 | 0.925 |
| High animal protein score | 1.048 | 0.773–1.420 | 0.761 | 1.297 | 1.142–1.474 | 6.540×10−5 | 1.353 | 1.106–1.655 | 0.003 |
| PPS, unadjusted | |||||||||
| Low plant protein score | 1.000 | REF | — | 1.000 | REF | — | 1.000 | REF | — |
| Moderate plant protein score | 0.839 | 0.662–1.064 | 0.147 | 0.872 | 0.789–0.963 | 0.007 | 0.839 | 0.721–0.976 | 0.023 |
| High plant protein score | 0.980 | 0.779–1.233 | 0.861 | 0.894 | 0.810–0.987 | 0.026 | 0.836 | 0.718–0.973 | 0.021 |
| PPS, adjusted | |||||||||
| Low plant protein score | 1.000 | REF | — | 1.000 | REF | — | 1.000 | REF | — |
| Moderate plant protein score | 0.755 | 0.549–1.039 | 0.084 | 0.856 | 0.752–0.975 | 0.020 | 0.830 | 0.676–1.020 | 0.076 |
| High plant protein score | 1.025 | 0.760–1.385 | 0.873 | 0.874 | 0.768–0.994 | 0.041 | 0.822 | 0.669–1.010 | 0.062 |
Abbreviations: AD, atopic dermatitis; APS, animal protein score; BMI, body mass index; CI, confidence interval; DPS, dietary protein score; HDM, house dust mite; IE, intrinsic eczema; PPS, plant protein score; REF, reference; SMCGES, Singapore/Malaysia Cross-sectional Genetic Epidemiology Study; SPT, skin prick test.
For results analyzed through multivariable logistic regression, the model adjusted for age, sex, BMI, and parental eczema, as confounding factors.
IE subject was defined to be positive for eczema symptoms if having a recurrent itchy rash that was coming and going for at least 6 months in flexural areas but testing negative for SPT reactivity to either one of the two common HDMs.
Allergic sensitization was compared between SPT-positive and SPT-negative subjects. SPT-positive subjects were determined by their reactivity to either one of the two common HDMs (Blomia tropicalis and Dermatophagoides pteronyssinus).
AD presentation was compared between an AD case and a nonallergic noneczema control. AD was defined in this study to be affirmative to positive SPT and having eczema symptoms.
Logistic regression P-value < 0.003 (after Bonferroni’s correction for multiple comparisons) is statistically significant and written in bold.