Table 4.
Odds of gastric cancer1 overall and according to histologic subtype based on selected chemical or environmental occupational exposures
| Gastric adenocarcinoma (any histologic subtype) | Intestinal-type adenocarcinoma | Diffuse adenocarcinoma | Mixed/Unclassified adenocarcinoma | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Studies2 | Exposure3 | Non-cancer controls (n=10487) | Cases | OR | (95%CI) | Cases | OR | (95% CI) | Cases | OR | (95% CI) | Cases | OR | (95% CI) |
| 7,10,12,14,15 | Pesticide/Herbicide | 1489 | 650 | 1.42 | (1.25–1.61) | 86 | 1.26 | (0.92–1.73) | 39 | 1.66 | (1.08–2.55) | 374 | 1.46 | (1.25–1.69) |
| 7,10,12,15 | Chromium | 843 | 345 | 1.51 | (1.30–1.76) | 39 | 1.14 | (0.76–1.72) | 23 | 1.84 | (1.09–3.11) | 283 | 1.55 | (1.32–1.82) |
| 7,10,12,15 | Asbestos | 1060 | 438 | 1.35 | (1.17–1.55) | 85 | 1.31 | (0.96–1.80) | 30 | 1.05 | (0.67–1.64) | 319 | 1.43 | (1.22–1.67) |
| 7,10,12,15 | Radiation and Magnetic Fields4 | 1071 | 426 | 1.30 | (1.13–1.50) | 81 | 1.17 | (0.85–1.60) | 48 | 2.01 | (1.33–3.06) | 287 | 1.26 | (1.07–1.47) |
| 7,10,12,15 | Wood Dust and Lumber Industry | 1520 | 510 | 1.33 | (1.16–1.52) | 46 | 1.51 | (1.01–2.26) | 25 | 2.52 | (1.46–4.33) | 434 | 1.29 | (1.11–1.49) |
| 10,12,15 | Aromatic Amine5 | 863 | 324 | 1.56 | (1.33–1.82) | 23 | 1.83 | (1.09–3.06) | 12 | 2.92 | (1.36–6.26) | 288 | 1.52 | (1.29–1.79) |
| 7,10,12 | Plastic Dust6 | 853 | 314 | 1.44 | (1.23–1.68) | 24 | 1.02 | (0.62–1.66) | 12 | 1.50 | (0.76–2.94) | 278 | 1.49 | (1.26–1.75) |
| 7,12,15 | Aromatic Hydrocarbons7 | 947 | 345 | 1.41 | (1.21–1.64) | 29 | 1.03 | (0.66–1.62) | 12 | 1.08 | (0.56–2.08) | 303 | 1.48 | (1.26–1.74) |
| 7,12,15 | Volatile Sulfur Compounds8 | 746 | 351 | 1.33 | (1.14–1.55) | 76 | 0.98 | (0.69–1.38) | 29 | 1.14 | (0.70–1.86) | 246 | 1.45 | (1.22–1.72) |
| 7,12,15 | Coal Derivatives9 | 1095 | 491 | 1.48 | (1.27–1.72) | 71 | 1.29 | (0.76–2.18) | 44 | 2.69 | (1.29–5.59) | 339 | 1.47 | (1.26–1.73) |
Models adjusted for study location, age, sex, education, smoking status, alcohol consumption, diet, GC family history, and H. pylori exposure. The reference group was defined a priori as subjects without exposure to that particular agent, or exposure for less than one-year (see text).
Includes subjects from studies 10-Italy 1 (De Feo et al., 2012), 12-Canada (Mao et al., 2002), 14-China (Mu et al., 2005), 15-USA (Zhang et al., 1999), and 7-Spain (Santibanez et al., 2012).
Selected exposures were a priori determined based on the International Association for Cancer Research (IARC) Monograph identifying these substances as carcinogenic or potentially carcinogenic (see text)
Defined as exposure to ‘UV rays’, ‘ionizing radiation’, ‘radiation sources’, ‘radiation’, and ‘low-frequency magnetic fields’
Defined as exposure to ‘aromatic amines’, ‘benzidine’, and ‘beta-naphthyl’
Defined as exposure to ‘vinyl chloride’ and ‘synthetic polymer dust’
Defined as exposure to ‘benzene’ and ‘aromatic hydrocarbon solvents’
Defined as exposure to ‘mustard gas’ and ‘volatile sulfur compounds’
Defined as exposure to ‘asphalt’, ‘coal tar’, ‘soot’, ‘pitch’, ‘creosote’, and ‘bitumen fumes’