Table 1.
Differentially expressed genes in the liver of WT and Bach1−/− mice after CLP.
| Gene symbol | Gene description | Fold change | adj. p-value (FDR) |
|---|---|---|---|
| Upregulated Genes | |||
| Hmox1a | Heme oxygenase 1 | 5.08 | 2.44 × 10−13 |
| Slc48a1a | Solute carrier family 48, member 1 | 2.51 | 1.20 × 10−10 |
| Ehhadh | Peroxisomal bifunctional enzyme | 3.78 | 3.12 × 10−06 |
| Rab36a | RAB36, member RAS oncogene family | 2.44 | 3.56 × 10−05 |
| Mup12 | Major urinary protein 12 | 2.04 | 3.56 × 10−05 |
| Cyp26b1 | Cytochrome P450, family 26, subfamily b, polypeptide 1 | 3.89 | 6.98 × 10−05 |
| Cyp4a32 | Cytochrome P450, family 4, subfamily a, polypeptide 32 | 2.87 | 1.38 × 10−03 |
| Abcb4 | ATP-binding cassette, sub-family B, member 4 | 1.60 | 1.64 × 10−03 |
| Trim80a | Tripartite motif-containing 80 | 4.22 | 2.14 × 10−3 |
| Asla | Argininosuccinate lyase | 1.81 | 2.86 × 10−03 |
| Gm15611 | Predicted gene 15611 | 3.84 | 3.00 × 10−03 |
| Lepra | Leptin receptor | 11.45 | 8.28 × 10−03 |
| Acaa1ba | Acetyl-Coenzyme A acyltransferase 1B | 2.35 | 8.28 × 10−03 |
| Elovl5a | ELOVL family member 5, elongation of long chain fatty acids | 2.01 | 1.15 × 10−02 |
| Crata | Carnitine acetyltransferase | 1.75 | 1.49 × 10−02 |
| Cyp4a10 | Cytochrome P450, family 4, subfamily a, polypeptide 10 | 2.39 | 2.74 × 10−02 |
| Chrna2 | Cholinergic receptor, nicotinic, alpha polypeptide 2 | 2.46 | 2.75 × 10−02 |
| Taok3a | TAO kinase 3 | 1.58 | 2.75 × 10−02 |
| Cyp7b1a | Cytochrome P450, family 7, subfamily b, polypeptide 1 | 1.70 | 3.66 × 10−02 |
| Cyp4a31 | Cytochrome P450, family 4, subfamily a, polypeptide 31 | 2.80 | 3.69 × 10−02 |
| Nipal1a | NIPA-like domain containing 1 | 3.49 | 4.69 × 10−02 |
| Abcc3a | ATP-binding cassette, sub-family C, member 3 | 1.73 | 4.69 × 10−02 |
| Retsata | Retinol saturase | 1.68 | 4.69 × 10−02 |
| Hmgcs2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 | 1.55 | 4.69 × 10−02 |
| Downregulated Genes | |||
| Btg2a | B cell translocation gene 2 | 0.35 | 3.62 × 10−08 |
| Slc25a25a | Solute carrier family 25, member 25 | 0.41 | 1.58 × 10−05 |
| Plk3a | Polo like kinase 3 | 0.45 | 5.40 × 10−04 |
| Fmo5 | Flavin containing monooxygenase 5 | 0.56 | 1.64 × 10−03 |
| Gas6a | Growth arrest specific 6 | 0.58 | 1.64 × 10−03 |
| Flnca | Filamin C, gamma | 0.01 | 2.01 × 10−03 |
| Slc41a2 | Solute carrier family 41, member 2 | 0.65 | 2.86 × 10−03 |
| Tgtp1 | T cell specific gtpase 1 | 0.23 | 5.57 × 10−03 |
| Mid1 | Midline 1 | 0.42 | 8.34 × 10−03 |
| Egr1a | Early growth response 1 | 0.35 | 1.63 × 10−02 |
| Lyz2 | Lysozyme 2 | 0.49 | 1.63 × 10−2 |
| Bach1 | Basic leucine zipper transcription factor 1 | 0.47 | 1.72 × 10−02 |
| Tceal8 | Transcription elongation factor A-like 8 | 0.44 | 2.39 × 10−02 |
| Arid5aa | AT rich interactive domain 5A | 0.37 | 2.74 × 10−02 |
| Gm29825 | Predicted gene, 29825 | 0.01 | 2.75 × 10−02 |
| Trim11 | Tripartite motif-containing 11 | 0.65 | 4.42 × 10−02 |
| Saa3 | Serum amyloid A 3 | 0.46 | 4.69 × 10−02 |
| Sema4ca | Semaphorin-4C | 0.30 | 4.75 × 10−02 |
| Zfp36a | Zinc finger protein 36 | 0.45 | 4.80 × 10−02 |
| Tmem267 | Transmembrane protein 267 | 0.28 | 4.91 × 10−02 |
a
Target genes of the BACH1 transcription factor in ChIP-seq data as extracted from the ENCODE Transcription Factor Targets dataset. Data source: Harmonizome.