Comparison 1. Silicone hydrogel versus hydrogel.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 OSDI scores	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.1.1 At 1 month	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.1.2 At 3 month	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.2 VAS scores	2		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.2.1 At one week, VAS 0 to 5 (higher is better)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.2.2 At three months, VAS 0 to 100 (higher is better)	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.3 Discontinuation of contact lens wear	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.3.1 ≤ 4 weeks	1	248	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.11, 3.74]
1.3.2 At 3 months	2	210	Risk Ratio (M‐H, Fixed, 95% CI)	3.53 [0.65, 19.08]
1.3.3 At 52 weeks	2	815	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.69, 1.11]
1.4 Corneal staining scores	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.5 Conjunctival staining score	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.6 Conjunctival redness scores	2		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.6.1 Nasal conjunctival redness	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.6.2 Temporal conjunctival redness	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.6.3 Limbal conjunctival redness	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.7 Proportion of vision‐threatening adverse events	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.7.1 ≤ 4 weeks	2	368	Risk Ratio (M‐H, Fixed, 95% CI)	0.68 [0.08, 5.51]
1.7.2 At 3 months	1	90	Risk Ratio (M‐H, Fixed, 95% CI)	3.56 [0.19, 66.72]
1.7.3 At 52 weeks	2	815	Risk Ratio (M‐H, Fixed, 95% CI)	2.03 [1.38, 2.99]