jRCT2052210025.

Methods	RCT, paired‐eye design
Participants	Inclusion criteria: age 20 years or older; refractive error (equivalent spherical power: −1.00 D to −6.00 D); subjective symptoms with SCL wear: eye discomfort (questionnaire score of 3 to 4 in each eye), itching (over 2 points in each eye); positive allergy test within the last year; astigmatism (less than or equal to −1.50 D); BCVA equal or better than 1.0 in each eye; habitual SCL wearers Exclusion criteria: moderate or higher corneal, conjunctival, and eyelid findings; allergic symptoms to antiallergic agents; eye diseases except for refractive error and allergic conjunctivitis; dry eye and lacrimal disorders; concomitantly prohibited drugs; history of anaphylaxis to sodium cromoglycate; previous hard contact lens use; refractive surgery; dry, high‐dust, and chemical living environments; pregnant or lactating
Interventions	2 types of daily disposable SCL (C‐BAC1423) worn at the same time (left or right eyes based on randomization) for 2 weeks Notes: lens material is unknown. No response to an email requesting clarification from investigators
Outcomes	Primary outcome: Side effects and adverse events Secondary outcomes: discontinued cases: subjective symptoms, slit lamp microscopic, and lens defects lens correction VA improvement of eye discomfort during wearing from the first visit to the second week
Notes	Sponsorship source: SEED Co. Ltd. Author's name: Kikue Nakamura Institution: SEED Co. Ltd. Comments: no trial results available