NCT01917162.

Methods	RCT, cross‐over design
Participants	Inclusion criteria: adapted SCL wearer; spherical distance contact lens prescription between −1.00 and −6.00 D; spectacle cylinder ≤ 0.75 D in the least astigmatic eye, ≤ 1.00 D in the other; correctable to 6/9 (20/30) in both eyes Exclusion criteria: a systemic or ocular disease that might interfere with contact lens wear; corneal refractive surgery and any anterior segment surgery; systemic or topical medication contraindicating contact lens wear; use of gas‐permeable contact lenses within 1 month preceding the study
Interventions	Nelfilcon A material: hydrogel replacement frequency: daily UltraFilcon B material: silicone hydrogel replacement frequency: daily
Outcomes	Primary outcome: Initial comfort (1‐to‐10 scale; 10 = cannot be felt, 1 = painful Secondary outcomes: end‐of‐day comfort (1‐to‐10 scale; 10 = cannot be felt, 1 = painful) overall comfort (1‐to‐10 scale; 10 = cannot be felt, 1 = painful) overall handling (1‐to‐10 scale; 10 = excellent, very easy; 1 = unmanageable)
Notes	Sponsorship source: Alcon Research Author's name: Joachim Nick Institution: Alcon Research Comments: no trial results available