NCT02920983.

Methods	RCT, cross‐over design
Participants	Inclusion criteria: age 18 years or older; contact lens spherical prescription between −1.00 and −6.00 D; cylindrical correction of −0.75 D or less; can attain at least 0.10 logMAR; currently use SCL or have done so in the previous 6 months; willing to wear SCL at least 5 days per week and for at least 8 hours per day Exclusion criteria: ocular or systemic disorder or treatments that would normally contraindicate contact lens wear; previous cataract or refractive surgery; previous hard contact lens wear; pregnant or lactating
Interventions	Somofilcon A material: silicon hydrogel replacement frequency: daily Nelfilcon A II 2 material: hydrogel replacement frequency: daily Omafilcon A ll 2 material: hydrogel replacement frequency: daily
Outcomes	Primary outcome: biomicroscopy (scale 0 to 4, 0.25 steps, 0 = normal, 4 = severe) Secondary outcomes: lens surface deposition, wettability (grades 0 to 4; 0 = normal, 1 = trace, 2 = mild, 3 = moderate, 4 = severe) lens wettability (grades 0 to 4; 0 = normal, 1 = trace, 2 = mild, 3 = moderate, 4 = severe) VA (logMAR) comfort (scale 0 to 100; 0 = causes pain, cannot be tolerated, 100 = excellent, cannot be felt) dryness (scale 0 to 100; 0 = extremely poor, high levels of dryness, 100 = excellent, no dryness) vision (scale 0 to 100; 0 = unacceptable, lens cannot be worn, 100 = excellent)
Notes	Sponsorship source: CooperVision Inc. Author's name: Carole Maldonado‐Codinal, PhD, FAAO Institution: Eurolens Research, University of Manchester Comments: whether the analysis accounted for cross‐over design was unclear