NCT04032457.

Methods	RCT, parallel‐group, cross‐over design
Participants	Inclusion criteria: 18 to 42 years of age; currently wearing spherical daily disposable contact lenses at least 5 days/week; vision correctable to 20/30 with spherical lenses in powers from +3.00 to +1.00 DS and from −1.00 to −7.00 DS; VA corrected to at least 20/30 with spherical contact lens Exclusion criteria: ocular or systemic disease that contraindicates SCL wear; sensitivity to diagnostic pharmaceuticals; pregnant, lactating, or planning pregnancy; aphakic; undergone refractive error surgery
Interventions	Phase 1 Olifilcon B with tangible coatings material: silicone hydrogel replacement frequency: daily Etafilcon A material: hydrogel replacement frequency: daily Senofilcon A material: silicone hydrogel replacement frequency: daily Delefilcon A material: silicone hydrogel replacement frequency: daily Phase 2 Etafilcon A with tangible coatings material: hydrogel replacement frequency: daily Etafilcon A material: hydrogel replacement frequency: daily Nesofilcon A material: hydrogel replacement frequency: daily Nelfilcon A material: hydrogel replacement frequency: daily Notes: 2 phases, only 6 parallel groups in phase A compared silicone hydrogel SCL to daily SCL in 12 cross‐over interventions (12 participants in each intervention period); the other 6 groups in phase B compared a new‐to‐market hydrogel SCL to daily SCL
Outcomes	Primary outcome: subjective lens preference Likert question (forced choice; test or benchmark lens or no preference) Secondary outcomes: CLDEQ‐8 score adverse outcomes
Notes	Sponsorship source: Vision Service Plan Authors' names: Robin L Chalmers, OD (investigator), Alex Dreu, Plexus Optix (results) Institution: Vision Service Plan, Foresight Regulatory Strategies Inc. Comments: quality control review of results not completed; whether the analysis accounted for cross‐over design was unclear