Table II.
Baseline main clinical and hematochemical characteristics of the subjects enrolled in the trial and randomized to the different treatments
| Parameters | Placebo (N = 20) | Dietary supplement with red yeast rice and artichoke (N = 20) | Armolipid Plus® (N = 20) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | 95% confidence interval | Mean | 95% confidence interval | Mean | 95% confidence interval | ||||
| Lower | Upper | Lower | Upper | Lower | Upper | ||||
| Age [years] | 52.0 | 45.3 | 58.6 | 47.3 | 42.4 | 52.1 | 52.7 | 47.2 | 58.2 |
| Waist circumference [cm] | 87.6 | 76.9 | 108.9 | 86.8 | 75.4 | 106.3 | 90.7 | 74.3 | 111.5 |
| Body mass index [kg/m2] | 24.7 | 23.1 | 26.3 | 24.2 | 22.7 | 25.7 | 25.1 | 24.1 | 26.9 |
| Systolic blood pressure [mm Hg] | 127.7 | 115.8 | 131.6 | 126.3 | 118.0 | 130.7 | 126.3 | 117.7 | 134.9 |
| Diastolic blood pressure [mm Hg] | 76.2 | 70.7 | 81.7 | 78.5 | 72.9 | 84.2 | 80.7 | 76.0 | 85.4 |
| Pulse pressure [mm Hg] | 47.5 | 41.9 | 53.1 | 45.8 | 41.9 | 49.7 | 45.6 | 37.9 | 53.3 |
| Total cholesterol [mg/dl] | 221.7 | 210.4 | 232.9 | 236.1 | 223.3 | 248.9 | 230.9 | 218.1 | 253.6 |
| HDL cholesterol [mg/dl] | 51.7 | 45.7 | 57.6 | 52.5 | 45.8 | 59.1 | 46.8 | 42.0 | 51.6 |
| Triglycerides [mg/dl] | 109.9 | 79.6 | 140.1 | 105.5 | 79.2 | 131.8 | 113.9 | 91.6 | 136.1 |
| LDL cholesterol [mg/dl] | 148.0 | 137.3 | 158.8 | 162.6 | 151.1 | 174.0 | 161.3 | 149.7 | 182.9 |
| Total cholesterol/HDL cholesterol ratio | 4.5 | 4.0 | 5.0 | 4.8 | 4.2 | 5.4 | 5.3 | 4.8 | 5.9 |
| LDL cholesterol/HDL cholesterol ratio | 3.0 | 2.7 | 3.4 | 3.3 | 2.8 | 3.9 | 3.8 | 3.3 | 4.3 |
| Apolipoprotein A1 [mg/dl] | 149.2 | 139.0 | 159.3 | 149.6 | 137.1 | 162.1 | 147.7 | 134.1 | 161.3 |
| Apolipoprotein B [mg/dl] | 91.6 | 84.5 | 98.6 | 95.3 | 87.8 | 102.8 | 105.0 | 95.1 | 114.8 |
| Apolipoprotein B/Apolipoprotein A1 ratio | 0.6 | 0.6 | 0.7 | 0.7 | 0.6 | 0.7 | 0.7 | 0.6 | 0.8 |
| HDL cholesterol/Apolipoprotein A1 ratio | 0.3 | 0.3 | 0.4 | 0.3 | 0.3 | 0.4 | 0.3 | 0.3 | 0.3 |
| LDL cholesterol/Apolipoprotein B ratio | 1.6 | 1.5 | 1.7 | 1.7 | 1.6 | 1.8 | 1.7 | 1.6 | 1.7 |
| Serum uric acid [mg/dl] | 5.4 | 4.6 | 6.2 | 5 | 4.4 | 5.6 | 5.3 | 4.8 | 5.9 |
| Glucose [mg/dl] | 89.5 | 85.1 | 93.8 | 87.8 | 83.2 | 92.3 | 92.2 | 86.1 | 98.3 |
| Creatinine [mg/dl] | 1.0 | 0.9 | 1.0 | 1.0 | 0.9 | 1.0 | 1.0 | 0.9 | 1.1 |
| Estimated glomerular filtration rate [ml/min/1.73 m2] | 81.7 | 80.2 | 91.0 | 85.6 | 80.2 | 91.0 | 80.1 | 74.2 | 86.0 |
| Creatinine kinase [U/l] | 121.8 | 91.3 | 152.3 | 156.3 | 115.4 | 197.1 | 138.0 | 98.0 | 177.9 |
| γ-glutamyltransferase [U/l] | 21.9 | 15.9 | 27.8 | 29.7 | 19.1 | 40.2 | 19.9 | 15.6 | 24.1 |
| Aspartate aminotransferase [U/l] | 19.3 | 17.1 | 21.5 | 23.4 | 18.3 | 28.5 | 21.3 | 19.0 | 23.6 |
| Alanine aminotransferase [U/l] | 22.0 | 17.5 | 26.4 | 26.5 | 18.1 | 34.9 | 24.4 | 19.4 | 29.3 |
| Aspartate aminotransferase/alanine aminotransferase ratio | 1.0 | 0.9 | 1.1 | 1.0 | 0.9 | 1.2 | 1.0 | 0.9 | 1.2 |
| Lipid accumulation product | 35.8 | 18.9 | 52.7 | 30.8 | 21.0 | 40.6 | 35.7 | 25.7 | 45.7 |
| Hepatic steatosis index | 33.5 | 32.2 | 34.8 | 33.2 | 32.1 | 34.3 | 34.4 | 32.8 | 36.0 |
HDL – high-density lipoprotein, LDL – low-density lipoprotein.