Figure 6.

Effect of ADF and/or exenatide on liver insulin phosphorylation signal protein expression levels in HFD-induced obesity in mice. A – IRS1 is insulin transmitting signals to intracellular pathways. B – PI3K. Values are mean ± SD (n = 10), analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test. ^{¶,*, #}p < 0.05; ^¶compared with NPD control group, *compared with HFD control group, ^#compared with exenatide treated group

IRS1 – insulin receptor substrate 1, PI3K – phosphatidylinositol 3-kinase, NPD – normal palatable diet, HFD – high-fat diet, ADF – alternate-day high-fat diet.