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| Compound | Bridge length | Stereochemistry | E. coli IC50 (μM) |
|---|---|---|---|
| MBDTA-2 | — | achiral | 47.0 ± 2.3 |
| 5a | n = 1 | rac (R,R and S,S) | 30.4 ± 1.8 |
| 5b | n = 1 | meso | 9.95 ± 0.6 |
| 8 | — | rac (R and S) | 77.4 ± 5.8 |
| 11a | n = 2 | meso | 42.0 ± 0.8 |
| 11b | n = 2 | rac (R,R and S,S) | 19.7 ± 1.5 |
| 15 | n = 3 | meso, rac (R,R and S,S) | 40.6 ± 3.0 |
