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. 2023 Sep 19;43:44. doi: 10.1186/s41232-023-00293-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The effect of the JAK inhibitor on osteoclastogenic bone resorption in the three different types of bone damage in autoimmune arthritis. A, B Representative TRAP⁺ staining (A) and the number of TRAP⁺ multinucleated cells per bone surface (B) of the calcaneocuboid joint of untreated (n = 4), CIA (n = 4), and CIA + JAKi mice (n = 6). C, D Representative TRAP⁺ staining (C) and the number of TRAP⁺ multinucleated cells per bone surface (D) of periarticular bone (proximal tibia) of untreated (n = 4), CIA (n = 4) and CIA + JAKi mice (n = 6). E, F Representative TRAP⁺ staining (E) and the number of TRAP⁺ multinucleated cells per bone surface (F) of lumbar vertebrae of untreated (n = 4), CIA (n = 4), and CIA + JAKi mice (n = 6). Scale bar: (100 μm, upper left; 50 μm, others) (A, E). (100 μm, upper left; 25 μm, others) (C). All data are expressed as the mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001; ****p < 0.0001; by one-way ANOVA with the Holm-Sidak multiple comparisons test (B, D, F)