Table 5.
Summary of the bioinformatics prediction against human transcriptome. For each investigated miRNA (Query), the most significant putative human target mRNAs, showing at least a percentage of maximum likelihood > 0.86, were listed and described as NCBI acronyms (Code) and in full (Description). The complete output of this bioinformatics analysis was reported in Supplemental material 2
| Query | Target | |
|---|---|---|
| Code | Description | |
| miR156a | DCC | Netrin receptor DCC |
| IGFBP3 | Insulin-like growth factor-binding protein 3 | |
| PRNP | Major prion protein | |
| miR156b | IGFBP3 | Insulin-like growth factor-binding protein 3 |
| HGF | Hepatocyte growth factor receptor | |
| OXR1 | Oxidation resistance protein 1 | |
| miR159 | CTSK | Cathepsin K |
| BCL2L1 | Bcl-2-like protein 1 | |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B | |
| miR159c-3p | TRAF2 | TNF receptor-associated factor 2 |
| CDKN2D | Cyclin-dependent kinase 4 inhibitor D | |
| MTA1 | Metastasis-associated protein 1 | |
| miR160a | AKT1 | RAC-alpha serine/threonine-protein kinase |
| CDKN2A | Cyclin-dependent kinase inhibitor 2A | |
| E2F4 | Transcription factor E2F4 | |
| miR160b-5p | BOK | Bcl-2-related ovarian killer protein |
| CDK2 | Cyclin-dependent kinase 2 | |
| MPV17 | Protein Mpv17 | |
| miR164d-5p | STAT5A | Signal transducer and activator of transcription 5A |
| CEACAM1 | Carcinoembryonic antigen-related cell adhesion molecule 1 | |
| EPX | Eosinophil peroxidase | |
| miR166f-3p | IRF3 | Interferon regulatory factor 3 |
| AVEN | Cell death regulator Aven | |
| MMP14 | Matrix metalloproteinase-14 | |
| miR166g-3p | HDAC6 | Histone deacetylase 6 |
| GPX3 | Glutathione peroxidase 3 | |
| CDK2 | Cyclin-dependent kinase 2 | |
| miR167d | NFKB1 | Nuclear factor NF-kappa-B p105 subunit |
| KISS | Metastasis-suppressor KiSS-1 | |
| SRXN1 | Sulfiredoxin-1 | |
| miR167e-5p | TNFSF11 | Tumor necrosis factor receptor superfamily member |
| GSK3B | Glycogen synthase kinase-3 beta | |
| MGAT5 | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase | |
| miR168-5p | TRAF2 | TNF receptor-associated factor 2 |
| KISS1R | KiSS-1 receptor | |
| APOE | Apolipoprotein E | |
| miR172b-3p | FASLG | FASLG receptor |
| REL | Proto-oncogene c-Rel | |
| GSR | Glutathione reductase | |
| miR172c | FASLG | FASLG receptor |
| CTBP1 | C-terminal-binding protein 1 | |
| miR172c-5p | TRAF3 | NF receptor-associated factor 3 |
| IGF1 | Insulin-like growth factor I | |
| PXDN | Peroxidasin homolog | |
| miR393c-5p | MMP9 | Matrix metalloproteinase-9 |
| GSK3B | Glycogen synthase kinase-3 beta | |
| EPX | Eosinophil peroxidase | |
| miR395c-3p | RET | Retinol-binding protein |
| TNFRSF1A | Tumor necrosis factor receptor type 1-associated DEATH domain protein | |
| MCAM | Cell surface glycoprotein MUC18 | |
| miR396a | CTNNA1 | Catenin alpha-1 |
| TNFRSF1B | TNF receptor-associated factor 2 | |
| NFKB1 | Nuclear factor NF-kappa-B p105 subunit | |
| miR396c-3p | RBL1 | Retinoblastoma-like protein 1 |
| HDAC2 | Histone deacetylase 2 | |
| HDAC1 | Histone deacetylase 2 | |
| miR396f-5p | DFFA | NA fragmentation factor subunit alpha |
| ANGPTL7 | Angiopoietin-related protein 7 | |
| CCNB1 | G2/mitotic-specific cyclin-B1 | |
| miR398b | SOCS3 | Suppressor of cytokine signaling 3 |
| ERB2 | Estrogen receptor b2 | |
| CDK4 | Cyclin-dependent kinase 4 | |
| miR398b-3p | TP53I3 | TP53I3 protein |
| PRKCD | Protein kinase C delta type | |
| ERB2 | Estrogen receptor b2 | |
| miR399c | MMP9 | Matrix metalloproteinase-9 |
| FASLG | FASLG receptor | |
| GSR | Glutathione reductase | |
| miR399d | LAMB1 | Laminin subunit beta-1 |
| BOK | Bcl-2-related ovarian killer protein | |
| GSR | Glutathione reductase | |
| miR399e-3p | TIMP1 | Metalloproteinase inhibitor 1 |
| CCS | Copper chaperone for superoxide dismutase | |
| IRF3 | Interferon regulatory factor 3 | |
| miR399f-3p | MMP9 | Matrix metalloproteinase-9 |
| CASP8 | Caspase-8 | |
| LPO | Lactoperoxidase | |
| miR403b-3p | IGF1R | Insulin-like growth factor 1 receptor |
| CASP8 | Caspase-8 | |
| STAT5A | Signal transducer and activator of transcription 5A | |
| miR482a | NOS2 | Nitric oxide synthase, inducible |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 | |
| SERPINE1 | Plasminogen activator inhibitor 1 RNA-binding protein | |
| miR2118 | CCS | Copper chaperone for superoxide dismutase |
| RELA | Bifunctional (p)ppGpp synthase/hydrolase RelA | |
| CXCR4 | C-X-C chemokine receptor type 4 | |
| miR3954b-5p | STAT5A | Signal transducer and activator of transcription 5A |
| IGF1R | Insulin-like growth factor 1 receptor | |
| CASP8 | Caspase-8 | |
| miR6300 | DUOX1 | Dual oxidase 1 |
| TPBG | Trophoblast glycoprotein | |
| IFNG | Interferon gamma | |