TABLE 2.

Clinical correlation of fluconazole MICs determined by two different methods for testing C. neoformans isolates from 35 Ugandan AIDS patients with meningitis^a

Fluconazole MIC (μg/ml)	No. of patients with the indicated clinical outcome by test method
	YNBb				NCCLS M27-Ac
	Tested	Cured	Failed	Diedd	Tested	Cured	Failed	Died
0.5	2			2
1.0	5	3	1	1
2.0	9	6	2	1	1			1
4.0	11	3	4	4	15	7	5	3
8.0	8	4	1	3	18	8	3	7
16					1	1

^aAll patients were treated with fluconazole at doses of 400 to 1,200 mg/day. 

^bYNB, microdilution method using yeast nitrogen base medium and spectrophotometric reading at 48 h. 

^cNCCLS M27-A, reference microdilution method read visually after 48 h of incubation. 

^dPatients who died within the first 10 weeks of therapy (five with positive CSF cultures).