Table 5.
Absorption, distribution, metabolism, and excretion (ADMET) and Ames’s prediction scores of amygdalin and sorafenib
| ADMET | TOPKAT Ames | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Solubility | Solubility level | Absorption level | BBB level | CYP2D6 | Hepatotoxicity | Hepatotoxicity prediction | PPB | PPB prediction | AlogP98 | Prediction | Probability | Enrichment | Scores | |
| Amygdalin | -0.924 | 4 | 3 | 4 | -4.92333 | -15.707 | FALSE | -15.6493 | FALSE | -2.403 | Non-Mutagen | 0.134463 | 0.240814 | -16.0437 |
| Sorafenib | -6.059 | 1 | 0 | 4 | -6.28535 | -0.741939 | TRUE | 6.00289 | TRUE | 4.175 | Non-Mutagen | 0.0531248 | 0.0951423 | -19.6956 |
TOPKAT; toxicity prediction. ADMET; absorption, distribution, metabolism, and excretion