Fig. 3. The addition of DVP on pyridine was applied to DMA-VP block copolymers (top left, uncharged state A) to trigger the disassembly of micelles encapsulating Nile red (top left). A nucleophile (thiol or amine) was applied to switch from the disassembled charged state (top right, charged state B) back to state A. Also, this chemistry was applied to crosslinked, DMA-VP statistical copolymers (bottom left) to switch between a swollen (bottom right) and unswollen (bottom left) gel state. The letter b denotes a block-, the letter s a statistical copolymer. Experiments typically conducted in pH 7.4 phosphate buffer (0.1 M for signal-induced, 0.5 M for autonomous CRN).