Fig. 4. 2-(Acetoxymethyl)acrylate (ME) and DVP were applied to solution of DMA-VP block copolymers with sulfonate-functionalised polyanions (poly(sodium 4-styrenesulfonate), PSS) (left, uncharged state A) to form complex coacervate core micelles (C3Ms, right, charged state B). A nucleophile was applied to switch back to state A, both in a signal-induced and autonomous manner. The letter b denotes a block-copolymer. Experiments typically conducted in pH 7.4 phosphate buffer (0.1 M for signal-induced, 0.25 M for autonomous CRN).