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. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: Neuron. 2022 Aug 29;110(20):3374–3388.e8. doi: 10.1016/j.neuron.2022.08.001

Figure 2: LC to dCA3 projecting cells are required for contextual memory formation.

Figure 2:

(A) Schematics of experimental design for surgery. Example image for virus spread in HP estimated with AAV-DIO-GFP injected together with CAV-cre. Scale bar, 300μm.

(B) Inhibition of LC cells projecting to dCA3 during exploration of context A impaired performance in contextual memory linking tested with a 5 hours interval. (Control, n=7; LC inhibited, n=8. Two-way repeated measures ANOVA, Sidak post hoc. #p <0.05, *p < 0.05, **p<0.01). Clozapine-N-oxide was given to all mice. * is used to depict significance within groups and # is used to show significance between groups for two-way RM ANOVA.

(C) Inhibition of LC cells projecting to dCA3 impaired contextual conditioning (control, n=8; LC inhibited, n=8; Two-way RM ANOVA, Sidak posthoc test; **p<0.001, ##p<0.01). Clozapine-N-oxide was given to all mice. * is used to depict significance within groups and # is used to show significance between groups for two-way RM ANOVA.

All results are mean ± s.e.m.