Skip to main content
. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: Neuron. 2022 Aug 29;110(20):3374–3388.e8. doi: 10.1016/j.neuron.2022.08.001

Figure 3: LC to dCA1 inhibition decreases novelty induced increases in neuronal excitability.

Figure 3:

(A) Experimental design for measuring dCA1 neuronal excitability.

(B) Representative traces showing adaptive firing responses to a 200pA current injection in dCA1 pyramidal neurons.

(C) Inhibition of LC cells projecting to dCA1 during context exploration reduced the firing rate of dCA1 neurons 5 hours later (Two-way repeated measures ANOVA; control n=15, LC inhibited n=15, #p<0.05). Clozapine-N-oxide was given to all mice. # is used to show significance between groups for two-way RM ANOVA.

All results are mean + s.e.m.