Table 3.

Various Risk Stratification Models of Smoldering Multiple Myeloma Progression

Risk Stratification Models of Smoldering Multiple Myeloma
Mayo 20/20/2 Score Model
Risk factors	Score
Bone marrow plasma cells >20%	1
M-protein> 2 g/dl	1
FLC ratio >20	1
Risk category	Progression Risk
0 - Low	10% at 2 years 23% at 5 years
1 - Intermediate	26% at 2 years 47% at 5 years
>2 - High	47% at 2 years 82% at 5 years
IMWG score model
Risk factors	Score
FLC ratio (involved to uninvolved)
0–10	0
>10–25	2
>25–40	3
>40	5
M-protein level (g/dl)
0–1.5	0
>1.5–3	3
>3	4
Bone marrow plasma cells in %
0–15	0
>15–20	2
>20–30	3
>30–40	5
>40	6
FISH t (4;14), t (14;16), +1q, del 13q, monosomy 13	2
Risk category	Progression Risk
0–4 – Low	4% at 2 years 20% at 5 years
5–8 – Low-intermediate	26% at 2 years 55% at 5 years
9–12 Intermediate	51% at 2 years 70% at 5 years
>12 – High	73% at 2 years 85% at 5 years
PETHEMA score model
Risk factors	Score
≥95% aberrant plasma cells in bone marrow by multiparameter flow cytometry	1
Presence of immunoparesis	1
Risk category (score)	Median TTP
0	NR
1	73 months
2	23 months