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Core factors involved in pelvic organ prolapse (POP). MMPs/TIMPs, matrix metal peptidases/tissue inhibitors of metalloproteinases; TGF-β1, transforming growth factor β1; miRNAs, microRNAs; LOXL1, lysyl oxidase-like 1; HOXA11, homeobox A11; IGF-1, insulin-like growth factor 1; FBLN5, fibulin-5; oxidative stress, inflammatory response, estrogen, and other potential biomarkers.
