IC50 values of the new compounds 12–17 against Vero normal cells and selectivity indices against the tumor cells.
| Comp. | Vero cells IC50 (μM) | Selectivity index | ||
|---|---|---|---|---|
| HT-29 | A549 | HCT-116 | ||
| 12 | 422.29 ± 6.17 | 24.47 | 22.50 | |
| 13 | 425.65 ± 2.42 | 15.23 | 21.95 | 22.69 |
| 14 | 491.03 ± 4.97 | 22.05 | 24.79 | 16.94 |
| 15 | 389.62 ± 2.95 | 28.73 | 21.89 | 28.15 |
| 16 | 123.28 ± 1.44 | 6.65 | 4.97 | 4.26 |
| 17 | 178.8 ± 1.67 | 3.79 | 16.42 | 19.50 |