The binding energies (ΔG) of the synthesized thiazolidine-2,4-dione derivatives and sorafenib against VEGFR-2.

Comp.	ΔG [kcal mol−1]	(Number of H-bonds)/amino acids	Number of hydrophobic bonds/amino acids
Sorafenib	−21.33	(5)/Cys917, Glu88, and Asp1044	(8)/Leu838, Ala864, Leu1033 Val914, Val846, Cys1043, Phe1045. Leu887, His1024, and Leu1017
12	−21.95	(3)/Cys917, Glu88, and Asp1044	(8)/Leu838, Phe916, Ala864, Leu1033, Val914, Val897, Phe1045, and Ile886
13	−21.84	(3)/Cys917, Glu88, and Asp1044	(9)/Leu838, Phe916, Ala864, Leu1033, Val914, Val897, Cys1043, Leu887, and Ile886
14	−24.15	(3)/Cys917, Glu88, and Asp1044	(9)/Leu838, Phe916, Ala864, Leu1033, Val914, Val897, Cys1043, and Ile886
15	−24.62	(3)/Cys917, Glu88, and Asp1044	(8)/Leu838, Phe1045, Ala864, Leu1033, Val914, Val897, Cys1043, Leu887, and Ile886
16	−24.05	(3)/Cys917, Glu88, and Asp1044	(8)/Leu838, Phe916, Ala864, Leu1033, Val914, Val897, Phe1045, Cys1043, and Leu887
17	−23.16	(3)/Cys917, Glu88, and Asp1044	(8)/Leu838, Phe1045, Ala864, Leu1033, Val914, Val897, Phe1045, Cys1043, Ile886, and Ile886