Table 1.

Summary of clinical stages of AD and associated NPS and treatment in comparison to MCI.

Clinical stage	MCI	Mild AD	Moderate AD	Severe AD
MMSE score	26+	>20	10–19	<9
Average duration of disease stage	4–10 Years	2–4 Years	2–10 Years	1–3 Years
Behavioral/Psychological symptoms reported	Apathy, Anhedonia	Apathy, Depression, some Anxiety	Apathy, Delusions, Major Depression, Anxiety, Insomnia, Agitation, Comprehension, Aggression	Apathy, decreased Depression, IADLs affected, Psychosis, Aggression, Agitation, Comprehension, worsened Insomnia
Current pharmacological therapies	Acetylcholinesterase Inhibitors, Donepezil	Acetylcholinesterase Inhibitors, Methylphenidate, SSRIs/SNRIs, Antidepressants, Carbamazepine, Donepezil	SSRIs/SNRIs, Lecanemab, Brexpirpazole, Benzodiazepines, Atypical Antipsychotics, Antidepressants	Atypical Antipsychotics, Benzodiazepines, Antidepressants