Table 5.

Safety analysis results of two groups of patients with knee arthritis.

Adverse events	Total (N = 250)	Flurbiprofen (N = 125)	Loxoprofen (N = 125)	P-value
Overall adverse events	49 (19.6)	7 (5.6)	42 (33.6)	<0.001
Skin irritation	16 (6.4)	4 (3.2)	12 (9.6)	0.039
Skin rash	15 (6.0)	2 (1.6)	13 (10.4)	0.003
Skin pain	11 (4.4)	2 (1.6)	9 (7.2)	0.031
Sticky hair uncovering pain	36 (14.4)	1 (0.8)	35 (28.0)	<0.001
Adverse event severity score*	0 (0–1.0)	0 (0)	0 (0–1.0)	<0.001

Data are presented as n (%) and median (interquartile range). ^*The severity of each adverse event was measured using a scale ranging from 0 to 4, with higher points indicating more severe conditions.