TABLE 2.
Comparison of Diagnostic Efficacy of AIGS in 2 Cohorts
| Performance factors | Total = 105 | P b | Total = 37 | P b | |||
|---|---|---|---|---|---|---|---|
| AIGS | AIGSa | IHC | AIGS | AIGSa | |||
| Accuracy | 96.2% | 100% | <.05 | 78.4% | 97.3% | 100% | <0.05 |
| Sensitivity | 93.5% | 100% | 91.7% | 91.7% | 100% | ||
| Specificity | 98.3% | 100% | 72% | 100% | 100% | ||
| Youden's index | 91.8% | 100% | 63.7% | 91.7% | 100% | ||
| PPV | 97.7% | 100% | 61.1% | 100% | 100% | ||
| NPV | 95.1% | 100% | 94.7% | 96.2% | 100% | ||
AIGS, automatic integrated gene detection system; IHC, immunohistochemistry; PPV, positive predictive value; NPV, negative predictive value.
a
Compared with NGS detection results, IDH2 mutation was excluded.
b
χ2 test of diagnostic consistency between AIGS and NGS.