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. 2023 Sep 19;18(9):e0291361. doi: 10.1371/journal.pone.0291361

Table 3. Summary of data including the results of the receptors and p53 immunostains, and Fisher’s Exact tests.

Diagnosis n ER PR AR p53
    +n +% +n +% +n +% +n +%
EEC 24 23 96% 23 96% 23 96% 3 13%
NEEC 28 13 46% 10 36% 19 68% 27 96%
SCA 13 11 85% 8 62% 12 92% 13 100%
CCCA 5 0 0% 0 0% 3 60% 5 100%
CS 4 2 50% 2 50% 4 100% 4 100%
DECA 5 0 0% 0 0% 0 0% 5 100%
MNCA 1 0 0% 0 0% 0 0% 0 0%
Met 1 1 100% 0 0% 1 100% 0 0%
All 53 37 70% 33 62% 43 81% 30 57%
2x2 Contingency Table Values Fisher’s Exact Test P-Values
Positive Negative ER vs p53 PR vs p53 AR vs p53
EEC ER 23 1 <0.0001
PR 23 1 <0.0001 <0.0001
AR 23 1
p53 3 21
NEEC ER 13 15 <0.0001
PR 10 18 <0.0001 0.01
AR 19 9
p53 27 1
Met ER 1 0 1*
PR 0 1 1 1
AR 1 0
p53 0 1
All ER 37 16 0.7
PR 33 20 0.2 0.01
AR 43 10
p53 30 23

ER, estrogen receptor; PR, progesterone receptor; AR, androgen receptor; +, positive reactions; EEC, endometrial endometrioid cancer, NEEC, non-endometrioid endometrial cancers which include: SCA, serous carcinoma; CCCA, clear cell carcinoma; CS, carcinosarcoma; DECA, dedifferentiated endometrial carcinoma; and MNCA, mesonephric like carcinoma; Met, metastatic carcinoma; p53, aberrant-expression as positive, wild-type as negative

*, although the statistical test did net return any result because of the two zeros, the p-value is assumed as "1" since both sets of data are identical.