Table 5. Summary of literature review delineating expression of the hormonal receptors in the endometrial malignancies.
Authors | Institution | Year | EEC | SCA | CCCA | CS | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AR | ER | PR | AR | ER | PR | AR | ER | PR | AR | ER | PR | |||||||
Tot | +n (+%) | +n (+%) | +n (+%) | Tot | +n (+%) | +n (+%) | +n (+%) | Tot | +n (+%) | +n (+%) | +n (+%) | Tot | +n (+%) | +n (+%) | +n (+%) | |||
Current series | UCLA | 2023 | 36 | 35 (97) | 35 (97) | 35 (97) | 13 | 12 (92) | 11 (85) | 8 (62) | 6 | 3 (50) | 0 (0) | 0 (0) | 6 | 6 (100) | 4 (67) | 3 (50) |
Cao et al. [23] | HNSM | 2021 | 9 | 6 (67) | 6 (67) | 2 (20) | 8 | 7 (88) | 4 (50) | 4 (50) | 12 | 1 (9) | 1 (9) | 1 (9) | 10 | 8 (80) | 8 (80) | 6 (60) |
Zadeh et al. [4] | UVC | 2018 | 20 | 11 (65) | 18 (90) | 17 (85) | 10 | 7 (70) | 8 (80) | 5 (50) | 10 | 3 (30) | 6 (60) | 1 (10) | 10 | 5 (50) | 4 (40) | 3 (30) |
Tangen et al. [14] | UIB | 2016 | 574 | 386 (67) | LP | LP | 65 | 36 (55) | LP | LP | 28 | 7 (25) | LP | LP | 32 | 13 (41) | LP | LP |
DECA | MNCA | Met | All | |||||||||||||||
AR | ER | PR | AR | ER | PR | AR | ER | PR | AR | ER | PR | |||||||
Tot | +n (+%) | +n (+%) | +n (+%) | Tot | +n (+%) | +n (+%) | +n (+%) | Tot | +n (+%) | +n (+%) | +n (+%) | Tot | +n (+%) | +n (+%) | +n (+%) | |||
Current series | UCLA | 2023 | 5 | 0 (0) | 0 (0) | 0 (0) | 1 | 0 (0) | 0 (0) | 0 (0) | 4 | 4 (100) | 4 (100) | 3 (75) | 71 | 60 (85) | 54 (76) | 49 (69) |
Cao et al. [23] | HNSM | 2021 | 16 | 10 (63) | NP | NP | NR | NR | NR | NR | NR | NR | 55 | 32 (58) | 19 (35) | 13 (24) | ||
Zadeh et al. [4] | UVC | 2018 | NR | NR | NR | NR | NR | NR | NR | NR | NR | 50 | 26 (52) | 36 (72) | 26 (52) | |||
Tangen et al. [14] | UIB | 2016 | 13 | 1 (7) | LP | LP | 0 (0) | LP | LP | Unclear data | 712 | 442 (62) | LP | LP | ||||
Total | 888 | 569 (64) | 109 (72) | 88 (50) |
EEC, endometrial endometrioid cancer; SCA, serous carcinoma; CCCA, clear cell carcinoma; CS, carcinosarcoma; DECA, dedifferentiated/undifferentiated endometrial carcinoma; MNCA, mesonephric like carcinoma; Met, metastatic carcinoma; Tot, total cases; AR, androgen receptor; ER, estrogen receptor; PR, progesterone receptor; +n, number of positives; +%, percentage of positives; NP, Data Not provided; NR, not reported; UCLA, University of California, Los Angeles; HNSM; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell School of Medicine, Hempstead, New York; UVC, University of Virginia, Charlottesville; UIB, University of Bergen, Norway; LP, ER & PR data were lumped together, therefore not represented in this table.