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. 2023 Sep 19;18(9):e0291645. doi: 10.1371/journal.pone.0291645

Fig 7. The distinct ecosystem in HCC patients with different MRPS score based on single cell analysis.

Fig 7

(A) Dotplot showing the percentage of expressed cells and average expression levels of cell marker genes of major cell types. (B) T-distributed Stochastic Neighbor Embedding plot of 34 cell clusters and 6 major cell types from 10 HCC samples. (C-D) Based on expression pattern of cell markers, T/NK cells could be re-clustered into 7 cell types. (E-F) Myeloid cells could be clustered into M1-like macrophages, M2-like macrophages, monocyte (mono), plasmacytoid DCs (pDCs), and conventional dendritic cells (cDCs) according to the expression pattern of cell markers. (G-H) B cells were subdivided into plasma, GC B, resting B, and activated B according to the expression pattern of cell markers. (I) the MRPS score of 10 HCC patients. (J-K) CellChat revealing cell–cell communication network via known ligand-receptor pairs in HCC samples with different MRPS score. (L) Low MRPS-derived NK, CD8+ cytotoxic T, activated B possessed a higher number of ligand-receptor pairs, whereas the CD4+ exhauster T, Th17-like and M2-like macrophage possessed fewer pairs.