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[Preprint]. 2023 Sep 5:2023.09.01.555962. [Version 1] doi: 10.1101/2023.09.01.555962

Fig. 8. Increased Ksp37 degranulation in NK cells correlate with lower estimated glomerular filtration rate (eGFR).

Fig. 8.

Percent Ksp37+ calculated as percent Ksp37+ NK cells in B cell coculture condition minus PBMC only condition. eGFR values were calculated with CKD-EPI formula and patients with graft failure were assigned eGFR = 10 mL/min. a Greater degranulation and decrease of %Ksp37+ in CD57–NKG2A+KIR− NK cells correlates with higher 2-year eGFR (n=47) and 5-year eGFR (n=58) in CTOT01. b Greater degranulation and decrease of %Ksp37+ in CD57–NKG2A+KIR− NK cells correlates with higher 6-month and 2-year eGFR (n=25) in validation cohort CTOT19. Patients with eGFR ≤ 10 mL/min are indicated in red. Correlation coefficient and p value shown for Pearson correlation.