Table 1.

Pearson correlation between the midlife and late-life ARIC and Lehallier’s PACs and chronological age and MAE, ARIC

The midlife ARIC and published PACs; Visit 2 (N = 2,993 in training set, N = 1,496 in test set)
	midlife ARIC PAC	midlife Lehallier’s PAC
Number of aptamers in PAC	788	415
Hyperparameter value (lambda)	0.11	1.03
Correlation in the training seta	0.92	0.82
Correlation in the test seta	0.80	0.76
MAE in the training seta	1.50	2.13
MAE in the test seta	2.19	2.39
The late-life ARIC and published PACs; Visit 5 (N = 630 in training set, N = 315 in test set)
	late-life ARIC PAC	late-life Lehallier’s PAC
Number of aptamers in PAC	135	415
Hyperparameter value (lambda)	0.46	4.42
Correlation in the training seta	0.84	0.84
Correlation in the test seta	0.71	0.63
MAE in the training seta	1.47	1.71
MAE in the test seta	2.36	2.37

Abbreviations: MAE - median absolute error; PAC - proteomic ageing clock.

^aAmong healthy participants at Visit 2 and Visit 5, we randomly selected two-thirds of healthy participants at each visit and used them as the training set at the corresponding visit; the remaining one-third of healthy participants at each visit was used as the test set at the corresponding visit.