Table 3.
The associations between age acceleration for the midlife ARIC and Lehallier's PACs and mortality; ARIC (1990–2019)
| No. of participants | No. of deaths | Total person-years | HR (95% CI)a per one SD of age acceleration |
||
|---|---|---|---|---|---|
| midlife ARIC PAC (SD=2.94 years) | midlife Lehallier’s PAC (SD=3.00 years) | ||||
|
| |||||
| All-cause mortality | 8,768 | 5,294 | 182,630 | 1.38 (1.34, 1.42) | 1.34 (1.30, 1.38) |
| CVD mortality (Fine and Gray model) | 8,768 | 1,734 | 182,630 | 1.20 (1.14, 1.27) | 1.19 (1.13, 1.25) |
| Cancer mortality (Fine and Gray model) | 8,768 | 1,516 | 182,630 | 1.04 (0.98, 1.10) | 1.05 (0.99, 1.12) |
| LRD mortality (Find and Gray model) | 8,768 | 522 | 182,630 | 1.36 (1.22, 1.51) | 1.30 (1.17, 1.45) |
Abbreviations: PAC - proteomic aging clock; BMI - body mass index; CVD - cardiovascular disease; LRD - lower respiratory disease; eGFR - estimated glomerular filtration rate; SD - standard deviation; HR - Hazard ratio; CI - confidence interval.
The model was adjusted for chronological age, gender, joint terms for race and study center (Black participants from Mississippi; Black participants from any other centers; White participants from Maryland; White participants from North Carolina; and White participants from Minnesota), education, BMI, smoking status, pack-years of smoking, alcohol intake, physical activity (at Visit 1), hormone replacement therapy, diabetes, hypertension, CVD, and eGFR at Visit 2.