Table 5.
The associations of age acceleration for the late-life ARIC and Lehallier’s PACs and the change in age acceleration from midlife to late life with mortality; ARIC (2011–2019)
| No. of participants | No. of deaths | Total person-years | HR (95%CI)a per one SD of age acceleration |
||
|---|---|---|---|---|---|
| late-life ARIC PAC (SD = 2.61 years) | late-life Lehallier’s PAC (SD = 2.54 years) | ||||
|
| |||||
| All-cause mortality | 4,553 | 1,123 | 29,356 | 1.65 (1.52, 1.79) | 1.58 (1.46, 1.72) |
| CVD mortality (Fine and Gray model) | 4,553 | 348 | 29,356 | 1.37 (1.18, 1.58) | 1.38 (1.19, 1.62) |
| Cancer mortality (Fine and Gray model) | 4,553 | 278 | 29,356 | 1.21 (1.02, 1.44) | 1.19 (1.02, 1.40) |
| LRD mortality (Fine and Gray model) | 4,553 | 128 | 29,356 | 1.68 (1.32, 2.12) | 1.57 (1.21, 2.03) |
|
| |||||
| The change in age acceleration from midlife to late lifeb | |||||
|
| |||||
| No. of participants | No. of deaths | Total person-years | HR (95%CI) per one SD of change in age acceleration (SD = 2.91 years) | ||
|
| |||||
| All-cause mortality | 2,707 | 736 | 17,081 | 1.71 (1.52, 1.94) | NAc |
| CVD mortality (Fine and Grey model) | 2,707 | 239 | 17,081 | 1.38 (1.13, 1.68) | |
| Cancer mortality (Fine and Grey model) | 2,707 | 172 | 17,081 | 1.30 (0.98, 1.71) | |
| LRD mortality (Fine and Gray model) | 2,707 | 94 | 17,081 | 1.46 (1.05, 2.04) | |
Abbreviations: PAC — proteomic aging clock; SD — standard deviation; BMI — body mass index; CVD — cardiovascular disease; LRD — lower respriatory disease; eGFR — estimated glomerular filtration rate. HR — Hazard ratio; CI — confidence interval.
The model was adjusted for chronological age, gender, joint terms for race and study center (Black participants from Mississippi; Black participants from any other centers; White participants from Maryland; White participants from North Carolina; and White participants from Minnesota), education, BMI, smoking status, pack-years of smoking, alcohol intake, physical activity, diabetes, hypertension, CVD, and eGFR at Visit 5.
The associations for the change in age acceleration was examined among the 2,707 participants who survived until Visit 5 after excluding the training sets at Visit 2 and at Visit 5 and the model was additionally adjusted for midlife age acceleration.
The associations between the change in age acceleration and mortality were examined using the ARIC PACs only because the ARIC PACs and published PACs showed similar associations with all mortality types.