FIG. 3.

Comparison of deduced amino acid sequences of the HCV HVR1 isolated from five patients, V to Z. Only residues differing from the reference sequence (V) are shown in the alignment. Isolate X1 was obtained from patient X as a minor clone. The actual number of plasmid clones obtained from each patient is shown to the right of the sequence. The phylogenetic tree of nucleotide sequences was constructed by the neighbor-joining method using 6 isolates from HD patients and 25 unrelated isolates, including a control cluster (•), as shown in Fig. 1B.